Hu Lab Publications

  1. Sharma, R., Smolkin, R. M., Chowdhury, P., Fernandez, K. C., Kim, Y., Cols, M., Alread, W., Yen, W.F., Hu, W., Wang, Z. M., Violante, S., Chaligné, R., Li, M. O., Cross, J. R., Chaudhuri, J. (2023) Distinct metabolic requirements regulate B cell activation and germinal center responses. Nat Immunol. 24(8):1358-1369.

    Commented in Nat Immunol 24(8):1217-1219 and Science Immunol 8(85):eadj4913.

  2. Glasner, A., Rose, S. A., Sharma, R., Gudjonson, H., Chu, T., Green, J. A., Rampersaud, S., Valdez, I. K., Andretta, E. S., Dhillon, B. S., Schizas, M., Dikiy, S., Mendoza, A., Hu, W., Wang, Z. M., Chaudhary, O., Xu, T., Mazutis, L., Rizzuto, G., Quintanal-Villalonga, A., Manoj, P., de Stanchina, E., Rudin, C. M., Pe'er, D., Rudensky, A. Y. (2023) Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies. Nat Immunol. 24(6):1020-1035.

  3. van der Veeken, J., Campbell, C., Pritykin, Y., Schizas, M., Verter, J., Hu, W., Wang, Z. M., Matheis, F., Mucida, D., Charbonnier, L. M., Chatila, T. A., Rudensky, A. Y. (2022) Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells. Immunity 12;55(7):1173-1184.

  4. Hu, W.*#, Wang, Z. M.*, Feng, Y., Schizas, M., Hoyos B., van der Veeken, J., Verter, J., Bou Puerto, R., and Rudensky, A.Y.# (2021) Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity. Nat Immunol 22(9):1163-1174. (*co-first authors, # co-corresponding authors).

    Commented in Nat Immunol 22(9) and Science Immunol 6(64). Recommended by Faculty Opinions.

  5. Jacobsen, J. T.*, Hu, W.*, Castro, T. B. R., Solem, S., Galante, A., Lin, Z., Alon, S. J., Mesin, L., Bilate, A. M., Schiepers, A., Shalek, A. K., Rudensky, A.Y., Victora, G. D. (2021) Expression of Foxp3 by T follicular helper cells in end-stage germinal centers. Science 373(6552):eabe5146. (*co-first authors).

  6. van der Veeken, J., Glasner, A., Zhong, Y., Hu, W., Wang, Z.M., Bou-Puerto, R., Charbonnier, L.M., Chatila, T.A., Leslie, C.S., and Rudensky, A.Y. (2020). The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries. Immunity 53, 971-984

    Commented in Immunity 53(5).

  7. Akbar, M. A., Mandraju, R., Tracy, C., Hu, W., Pasare, C., Krämer, H. (2016) ARC Syndrome-Linked Vps33B

    Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination. Immunity 45, 267-79.

  8. Hu, W., Jain, A., Gao, Y., Dozmorov, I. M., Mandraju, R., Wakeland, E. K., Pasare, C. (2015) Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation. Proc Natl Acad Sci U S A 112, 13994-9.

  9. Lin, K. M*., Hu, W.*, Troutman, T. D., Jennings, M., Brewer, T., Li, X., Nanda, S., Cohen, P., Thomas, J. A., Pasare, C. (2014) IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proc Natl Acad Sci U S A 111, 775-80. (*co-first authors).

  10. Furlan, S. N., Mandraju, R., Brewer, T., Roybal, K., Troutman, T. D., Hu, W., Palm, N. W., Unni, A., Pasare, C. (2014) Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors. MAbs 6, 108-18.

  11. Hu, W., Pasare, C. (2013) Location, location, location: Tissue-specific regulation of immune responses. J Leukoc Biol 94, 409-21. (Invited review article).

  12. Troutman, T. D., Hu, W., Fulenchek, S., Yamazaki, T., Kurosaki, T., Bazan, J. F., Pasare, C. (2012) Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proc Natl Acad Sci U S A 109, 273-8.

  13. Hu, W., Troutman, T. D., Edukulla, R., Pasare, C. (2011) Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment. Immunity 35, 1010-22.

    Commented in Nat Rev Immunol 12(6). Recommended by Faculty Opnions.

  14. Yang, F., Hu, W., Xu, H., Li, C., Xia, B., Jin, C. (2007) Solution structure and backbone dynamics of an endopeptidase HycI from Escherichia coli: implications for mechanism of the [NiFe] hydrogenase maturation. J Biol Chem 282, 3856-63.

  15. Lescop, E., Hu, Y., Xu, H., Hu, W., Chen, J., Xia, B., Jin, C. (2006) The solution structure of Escherichia coli Wzb reveals a novel substrate recognition mechanism of prokaryotic low molecular weight protein-tyrosine phosphatases. J Biol Chem 281, 19570-7